Why you should avoid REGULAR acetaminophen use for babies and pregnancy 3 Little Plums Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Illustration of the effects of acetaminophen on glutathione, Download Scientific Diagram What Is Acetaminophen? Definition, Uses, Side Effects, and Risks Olympic Behavioral Health