Does Glutathione IV and Vitamin Supplements with Glutathione Have Any Negative Side Effects? For CKD, I'd separate the proven support from the experimental but interesting category. Astragalus root extract is probably the most tried and true natural compound I'd look at first. There's actual human data showing Glutathione Treatment Portland Skin Brightening The Dark Truth About Glutathione & Skin Whitening Risks, Myths & Facts Functions of Glutathione in Liver and Kidney Springer Nature Link