Cagrilintide (AM833) Long acting amylin analog. Beta cells make TWO hormones: insulin and amylin. Amylin slows stomach emptying and reduces appetite. Cagrilintide is a long acting synthetic amylin designed for once weekly dosing Structural and mechanistic insights into dual activation of cagrilintide in amylin and calcitonin receptors Acta Pharmacologica Sinica Cagrilintide Weight Loss Appetite Control and Fat Burning Support Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors Nature Communications Amylin as a future obesity treatment introducing cagrilintideNote significant GI adverse effects cf. placebo but no apparent plateauing of weight loss after 26 weeks