Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in COM Dec. 2011 Diagnosis UW School of Dentistry Labial melanotic macule. B). Increased numbers of me lanocytes along Download Scientific Diagram This patient has multiple labial melanotic macules. These are essentially freckles of the lips. These most commonly involve the lower lip. This patient had involvement of both the upper and lower lips. Oral Melanotic Macule: Symptoms and Treatment Skinsight